Norton, Nadine, Williams, Nigel Melville, O'Donovan, Michael Conlon and Owen, Michael John 2004. DNA pooling as a tool for large-scale association studies in complex traits. Annals of Medicine 36 (2) , pp. 146-152. 10.1080/07853890310021724 |
Official URL: http://dx.doi.org/10.1080/07853890310021724
Abstract
Pooled genotyping is a powerful and efficient tool for high throughput association analysis, both case-control and family-based. The use of pooling designs can significantly reduce the consumable and labour costs of a study. At the same time, since it is also extremely efficient with DNA resources, pooling can be an extremely effective method for conserving DNA. Here, we consider the main points in study design, and illustrate the application of pooling using psychiatric phenotypes as an example.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Neuroscience and Mental Health Research Institute (NMHRI) |
Subjects: | R Medicine > R Medicine (General) |
Publisher: | Informa Healthcare |
ISSN: | 0785-3890 |
Last Modified: | 24 Jan 2018 21:35 |
URI: | http://orca.cf.ac.uk/id/eprint/81789 |
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