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5-HT2A receptor and bipolar affective disorder: association studies in affected patients

Arranz, M. J., Erdmann, J., Kirov, George, Rietschel, M., Sodhi, M., Albus, M., Ball, D., Maier, W., Davies, N., Franzek, E., Abusaad, I., Weigelt, B., Murray, R., Shimron-Abarbanell, D., Kerwin, R., Propping, P., Sham, P., Nothen, N. M. and Collier, D. M. 1997. 5-HT2A receptor and bipolar affective disorder: association studies in affected patients. Neuroscience Letters 224 (2) , pp. 95-98. 10.1016/S0304-3940(97)13456-5

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The aim of this study was to investigate the possible involvement of genetic variation in serotonin receptors in the aetiology of bipolar affective disorder. The 5-HT2A receptor gene was systematically screened for genetic variants by single strand conformation polymorphism (SSCP) methods in subjects with bipolar affective disorder. Four polymorphisms (two structural changes, Thr25Asn and His4 M52Tyr, and two silent polymorphisms, 102-T/C and 516-C/T) which had previously been found in patients with schizophrenia and control subjects were detected. No novel polymorphisms were found in patients with bipolar affective disorder. These polymorphisms were genotyped in a sample of 129 patients and 252 controls of German origin and 176 patients and 182 controls of British origin. No strong associations were found between any of these polymorphisms and bipolar affective disorder. Genetic variation at the 5-HT2A receptor gene does not play a major role in the pathogenesis of the disorder.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > R Medicine (General)
Publisher: Neuroscience letters
ISSN: 0304-3940
Last Modified: 04 Jun 2017 08:38

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