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No evidence of association between HLA-DRB1 and attention deficit hyperactivity disorder.

Payton, A., Turic, D., Langley, Kate, Mills, S., Lawson, D.C., van den Bree, Marianne Bernadette, Owen, Michael John, O'Donovan, Michael Conlon, Ollier, W., Worthington, J. and Thapar, Anita 2003. No evidence of association between HLA-DRB1 and attention deficit hyperactivity disorder. Psychiatric Genetics 13 (3) , pp. 183-185.

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Abstract

OBJECTIVES: There has been a recent resurgence in interest in the role of autoimmunity in childhood neuropsychiatric disorders. Significant association between HLA-DRB1 and attention deficit hyperactivity disorder (ADHD) in a case-control study of 31 subjects has been reported but there have been no other published studies following up these results. We attempted to replicate these findings. METHODS: In a well-characterized sample of 173 children with ADHD, using a fully automated sequence-specific oligonucleotide method for HLA genotyping, association between ADHD and HLA-DRB1 was tested for using the Transmission Disequilibrium Test and case-control analysis. RESULTS: Transmission Disequilibrium Test analysis yielded a chi-square of 10.694 with a simulated global P value of 0.1641 for the full sample, and a chi-square value of 11.307 with a simulated global P value of 0.1323 for the complete trios only. CONCLUSION: There was no evidence of association of HLA-DRB1 and ADHD.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Publisher: Lippincott Williams & Wilkins
ISSN: 0955-8829
Last Modified: 21 Jun 2019 20:11
URI: http://orca.cf.ac.uk/id/eprint/82068

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