Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Genetic influences on the development of childhood psychiatric disorders

Thapar, Anita and Stergiakouli, E. 2008. Genetic influences on the development of childhood psychiatric disorders. Psychiatry 7 (7) , pp. 277-281.

Full text not available from this repository.

Abstract

This review covers the key types of genetic research design, the methodology involved and emerging, and established findings in relation to child and adolescent psychiatry. Traditional family, twin, and adoption studies show that child and adolescent psychiatric disorders are familial and genetically influenced. Genes and environment contribute to all disorders. Genetic factors seem especially important for autism and attention deficit hyperactivity disorder. Twin and adoption study designs are now being used to examine gene-environment interplay, the effects of environmental risk factors, co-morbidity, phenotype definition, and developmental change. Molecular genetic strategies are increasingly being adopted to identify gene variants that increase risk of specific disorders. The ways in which specific gene variants exert risk effects at cellular and biological system levels are proving to be highly complex. There is also interest in examining the brain mechanisms that may be involved in risk pathways that link gene variant to psychopathology. Finally, molecular genetic studies also highlight the importance of gene-environment interplay, which seems to be especially important in depression and antisocial behaviour.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Publisher: Elsevier
ISSN: 1476-1793
Last Modified: 04 Jun 2017 08:39
URI: http://orca.cf.ac.uk/id/eprint/82105

Citation Data

Cited 7 times in Google Scholar. View in Google Scholar

Cited 3 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item