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Micromechanical response of articular cartilage to tensile load measured using nonlinear microscopy

Bell, James Stephen, Christmas, J., Mansfield, Jessica C., Everson, R. M. and Winlove, C. Peter 2014. Micromechanical response of articular cartilage to tensile load measured using nonlinear microscopy. Acta Biomaterialia 10 (6) , pp. 2574-2581. 10.1016/j.actbio.2014.02.008

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Articular cartilage (AC) is a highly anisotropic biomaterial, and its complex mechanical properties have been a topic of intense investigation for over 60 years. Recent advances in the field of nonlinear optics allow the individual constituents of AC to be imaged in living tissue without the need for exogenous contrast agents. Combining mechanical testing with nonlinear microscopy provides a wealth of information about microscopic responses to load. This work investigates the inhomogeneous distribution of strain in loaded AC by tracking the movement and morphological changes of individual chondrocytes using point pattern matching and Bayesian modeling. This information can be used to inform models of mechanotransduction and pathogenesis, and is readily extendable to various other connective tissues.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Optometry and Vision Sciences
Uncontrolled Keywords: Cartilage; Biomechanics; Microstructure; Nonlinear microscopy; Bayesian modeling
Publisher: Elsevier
ISSN: 1742-7061
Date of Acceptance: 3 February 2014
Last Modified: 25 Feb 2019 11:57

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