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Suggestive evidence for linkage of schizophrenia to markers on chromosome 13q14.1-q32

Lin, M. W., Curtis, D., Williams, Nigel Melville, Arranz, M., Nanko, S., Collier, D., McGuffin, P., Murray, R., Owen, Michael John and Gill, M. 1995. Suggestive evidence for linkage of schizophrenia to markers on chromosome 13q14.1-q32. Psychiatric Genetics 5 (3) , pp. 117-126. 10.1097/00041444-199505030-00004

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Family, twin and adoption studies highlight the influence of genes in the aetiology of schizophrenia, though the mode of inheritance is unclear. We have been conducting a systematic search for major genes in schizophrenia using a series of multiply affected families and report preliminary results of linkage under heterogeneity with markers on chromosome 13. A lod2 score of 1.61 for marker D13S144 was obtained at theta = 0 and alpha of 0.5 and nearby markers also produced positive values.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Publisher: Lippincott Williams & Wilkins
ISSN: 0955-8829
Last Modified: 20 Jun 2020 14:46

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