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Repeat length variation in the dopamine D4 receptor gene shows no evidence of association with schizophrenia

Daniels, J., Williams, Julie, Mant, R., Asherson, P., McGuffin, P. and Owen, Michael John 1994. Repeat length variation in the dopamine D4 receptor gene shows no evidence of association with schizophrenia. American Journal of Medical Genetics 54 (3) , pp. 256-258. 10.1002/ajmg.1320540313

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Abstract

The D4 receptor has been shown to exist in several allelic forms (Van Tol et al., Nature 358:149-152, 1992) reflecting variation in the number of 48 base-pair sequence repeats in the putative cytoplasmic loop. We report a comparison of repeat length variation between schizophrenic patients and controls. Our sample of 106 unrelated schizophrenic cases and 119 controls showed no significant differences in allele or genotype distribution between patients and controls. In particular, we were unable to support the previous observation of an excess of 4-repeat homozygotes in patients.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Publisher: Wiley
ISSN: 0148-7299
Last Modified: 04 Jun 2017 08:40
URI: http://orca.cf.ac.uk/id/eprint/82341

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