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IQ and variation in the number of fragile X CGG repeats: No association in a normal sample

Daniels, J.K., Owen, Michael John, McGuffin, Peter, Thompson, Lee, Detterman, Douglas K., Chorney, Michael, Chorney, Karen, Smith, Deborah, Skuder, Patricia, Vignetti, Sylvia, McClearn, Gerald E. and Plomin, Robert 1994. IQ and variation in the number of fragile X CGG repeats: No association in a normal sample. Intelligence 19 (1) , pp. 45-50. 10.1016/0160-2896(94)90052-3

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Abstract

Fragile X mental retardation is associated with an unstable expansion of a CGG repeat in the FMR-1 gene on the X chromosome (Xq27.3). We asked whether variation in the number of FMR-1 CGG repeats relates to IQ in the general population. FMR-1 CGG repeats were genotyped for three groups: low IQ (mean IQ = 71, N = 35), middle IQ (mean IQ = 103, N = 19), and high IQ (mean IQ = 137, N = 49). The IQ groups did not differ significantly in number of FMR-1 CGG repeats for males or females.

Item Type: Article
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
ISSN: 01602896
Last Modified: 04 Jun 2017 08:40
URI: http://orca.cf.ac.uk/id/eprint/82380

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