A placebo-controlled, cross-over trial of lamotrigine in depersonalization disorder

Sierra, M., Phillips, Mary L., Ivin, G., Krystal, J. and David, A. S. 2003. A placebo-controlled, cross-over trial of lamotrigine in depersonalization disorder. Journal of Psychopharmacology 17 (1) , pp. 103-105. 10.1177/0269881103017001712

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Abstract

There is evidence to support the view that glutamate hyperactivity might be relevant to the neurobiology of depersonalization. We tested the efficacy of lamotrigine, which reduces glutamate release, as a treatment for patients with depersonalization disorder. A double-blind, placebo-controlled, cross-over design was used to evaluate 12 weeks of treatment of lamotrigine. Subjects comprised nine patients with DSM-IV depersonalization disorder. Changes on the Cambridge Depersonalization Scale and the Present State Examination depersonalization/derealization items were compared across the two cross-over periods. Lamotrigine was not significantly superior to placebo. None of the nine patients was deemed a responder to the lamotrigine arm of the cross-over. Lamotrigine does not seem to be useful as a sole medication in the treatment of depersonalization disorder.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	SAGE Publications
ISSN:	0269-8811
Last Modified:	30 Nov 2015 12:17
URI:	https://orca.cardiff.ac.uk/id/eprint/82629

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