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Different motile behaviors of human hematopoietic stem versus progenitor cells at the osteoblastic niche

Foster, Katie, Lassailly, François, Dos Anjos Afonso, Fernando, Currie, Erin, Rouault-Pierre, Kevin and Bonnet, Dominique 2015. Different motile behaviors of human hematopoietic stem versus progenitor cells at the osteoblastic niche. Stem Cell Reports 5 (5) , pp. 690-701. 10.1016/j.stemcr.2015.09.003

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Abstract

Despite advances in our understanding of interactions between mouse hematopoietic stem cells (HSCs) and their niche, little is known about communication between human HSCs and the microenvironment. Using a xenotransplantation model and intravital imaging, we demonstrate that human HSCs display distinct motile behaviors to their hematopoietic progenitor cell (HPC) counterparts, and the same pattern can be found between mouse HSCs and HPCs. HSCs become significantly less motile after transplantation, while progenitor cells remain motile. We show that human HSCs take longer to find their niche than previously expected and suggest that the niche be defined as the position where HSCs stop moving. Intravital imaging is the only technique to determine where in the bone marrow stem cells stop moving, and future analyses should focus on the environment surrounding the HSC at this point

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > QH Natural history > QH426 Genetics
Additional Information: Open Access funded by Cancer Research UK. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Publisher: Elsevier
ISSN: 2213-6711
Funders: Cancer Research UK
Date of First Compliant Deposit: 30 March 2016
Date of Acceptance: 8 September 2015
Last Modified: 15 Mar 2019 12:13
URI: http://orca.cf.ac.uk/id/eprint/82646

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