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Biotechnological promises of Fe-filled CNTs for cell translations and magnetic fluid hyperthermia applications

Pineaux, F., Stopin, Antoine and Bonifazi, Davide 2015. Biotechnological promises of Fe-filled CNTs for cell translations and magnetic fluid hyperthermia applications. Nanoscale 7 , pp. 20474-20488. 10.1039/C5NR04824A

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Abstract

Fe-filled carbon nanotubes (Fe@CNTs) recently emerged as an effective class of hybrid nanoparticles for biotechnological applications, such as magnetic cell sorting and magnetic fluid hyperthermia. Aiming at studying the effects of both the Fe loading and the magnetocrystalline characteristics in these applications, we describe herein the preparation of Fe@CNTs containing different Fe phases that, upon functionalization with the antibody Cetuximab (Ctxb), allow the targeting of cancer cells. Our experimental findings reveal that an optimal Ctxb/Fe weight ratio of 1.2 is needed for efficient magnetic cell shepherding, whereas enhanced MFH-induced mortality (70 vs. 15%) can be reached with hybrids enriched in the coercive Fe3C phase. These results suggest that a synergistic effect between the Ab loading and the Fe distribution in each nanotube exists, for which the maximum shepherding and hyperthermia effects are observed when higher densities of Fe@CNTs featuring the more coercive phase are interfaced with the cells.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Publisher: Royal Society of Chemistry
ISSN: 2040-3372
Date of Acceptance: 31 August 2015
Last Modified: 21 Nov 2019 23:40
URI: http://orca.cf.ac.uk/id/eprint/82696

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