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Cortical OFF-potentials from the S-cone pathway reveal neural damage in early glaucoma

H. Aldebasi, Yousef, Drasdo, Neville, Morgan, James Edwards and V. North, Rachel 2003. Cortical OFF-potentials from the S-cone pathway reveal neural damage in early glaucoma. Vision Research 43 (2) , pp. 221-226. 10.1016/S0042-6989(02)00435-2

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Abstract

We used background adaptation and silent substitution techniques to record full-field ON and OFF-visually evoked cortical potentials (VECPs) selectively from the S-cone and L- and M-cone pathways in 15 patients with primary open angle glaucoma (POAG), and 15 normal controls. The most statistically significant (P=0.01) VECP test for POAG was a voltage change in the S-cone pathway cortical OFF-response. A sensitivity of 93% was achieved, with 60% specificity at minimum error rate. This is presumed to reflect reduced activity in the S-cone and magnocellular visual pathways, and may provide an effective method for research and monitoring change in early glaucoma.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: Elsevier
ISSN: 0042-6989
Last Modified: 04 Jun 2017 08:41
URI: http://orca.cf.ac.uk/id/eprint/82815

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