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Perirhinal cortex lesions impair tests of object recognition memory yet spare novelty detection

Olarte-Sánchez, Cristian M., Amin, Eman, Clea Warburton, E. and Aggleton, John Patrick 2015. Perirhinal cortex lesions impair tests of object recognition memory yet spare novelty detection. European Journal of Neuroscience 42 (12) , pp. 3117-3127. 10.1111/ejn.13106

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Abstract

The present study examined why perirhinal cortex lesions in rats impair the spontaneous ability to select novel objects in preference to familiar objects, when both classes of object are presented simultaneously. The study began by repeating this standard finding, using a test of delayed object recognition memory. As expected, the perirhinal cortex lesions reduced the difference in exploration times for novel vs. familiar stimuli. In contrast, the same rats with perirhinal cortex lesions appeared to perform normally when the preferential exploration of novel vs. familiar objects was tested sequentially, i.e. when each trial consisted of only novel or only familiar objects. In addition, there was no indication that the perirhinal cortex lesions reduced total levels of object exploration for novel objects, as would be predicted if the lesions caused novel stimuli to appear familiar. Together, the results show that, in the absence of perirhinal cortex tissue, rats still receive signals of object novelty, although they may fail to link that information to the appropriate object. Consequently, these rats are impaired in discriminating the source of object novelty signals, leading to deficits on simultaneous choice tests of recognition.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Psychology
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Additional Information: Article first published online: 24 NOV 2015 This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Publisher: Federation of European Neuroscience Societies
ISSN: 0953-816X
Funders: Wellcome Trust
Date of First Compliant Deposit: 30 March 2016
Date of Acceptance: 13 October 2015
Last Modified: 25 Dec 2017 20:51
URI: http://orca.cf.ac.uk/id/eprint/83426

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