Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

The role of death-associated protein 3 in apoptosis, anoikis and human cancer

Wazir, Umar, Orakzai, Mona M.A.W., Khanzada, Zubair S., Jiang, Wen Guo, Sharma, Anup K., Kasem, Abdul and Mokbel, Kefah 2015. The role of death-associated protein 3 in apoptosis, anoikis and human cancer. Cancer Cell International 15 , 39. 10.1186/s12935-015-0187-z

PDF - Published Version
Available under License Creative Commons Attribution.

Download (1MB) | Preview


Death-associated protein 3 (DAP3) is a molecule with a significant role in the control of both apoptosis and anoikis. Apoptosis is the predominant type of programmed cell death (PCD) which may occur in response to irreparable damage to DNA, or in response to induction by inflammatory cells. Anoikis is subset of apoptosis which occurs in epithelial cells in response to detachment from the surrounding matrix. Both apoptosis and anoikis are of interest in the context of carcinogenesis. In this review, we shall discuss apoptosis and anoikis, and the recent literature regarding the role of DAP3 in both these pathways.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords: Apoptosis Review Death-associated protein 3 Anoikis Cancer Carcinogenesis Oncogenesis Breast cancer
Publisher: BioMed Central
ISSN: 1475-2867
Funders: Breast Cancer Hope Foundation
Date of First Compliant Deposit: 30 March 2016
Date of Acceptance: 18 March 2015
Last Modified: 10 Jun 2019 14:38

Citation Data

Cited 5 times in Google Scholar. View in Google Scholar

Cited 6 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item


Downloads per month over past year

View more statistics