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T cell antigen receptor recognition of antigen-presenting molecules

Rossjohn, Jamie, Gras, Stephanie, Miles, John James, Turner, Stephen J., Godfrey, Dale I. and McCluskey, James 2015. T cell antigen receptor recognition of antigen-presenting molecules. Annual Review of Immunology 33 (1) , pp. 169-200. 10.1146/annurev-immunol-032414-112334

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Abstract

The Major Histocompatibility Complex (MHC) locus encodes classical MHC class I and MHC class II molecules and nonclassical MHC-I molecules. The architecture of these molecules is ideally suited to capture and present an array of peptide antigens (Ags). In addition, the CD1 family members and MR1 are MHC class I–like molecules that bind lipid-based Ags and vitamin B precursors, respectively. These Ag-bound molecules are subsequently recognized by T cell antigen receptors (TCRs) expressed on the surface of T lymphocytes. Structural and associated functional studies have been highly informative in providing insight into these interactions, which are crucial to immunity, and how they can lead to aberrant T cell reactivity. Investigators have determined over thirty unique TCR-peptide-MHC-I complex structures and twenty unique TCR-peptide-MHC-II complex structures. These investigations have shown a broad consensus in docking geometry and provided insight into MHC restriction. Structural studies on TCR-mediated recognition of lipid and metabolite Ags have been mostly confined to TCRs from innate-like natural killer T cells and mucosal-associated invariant T cells, respectively. These studies revealed clear differences between TCR-lipid-CD1, TCR-metabolite-MR1, and TCR-peptide-MHC recognition. Accordingly, TCRs show remarkable structural and biological versatility in engaging different classes of Ag that are presented by polymorphic and monomorphic Ag-presenting molecules of the immune system.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: major histocompatibility complex, CD1, MR1, T cell antigen receptor
Publisher: Annual Reviews
ISSN: 0732-0582
Last Modified: 11 Jun 2019 12:51
URI: http://orca.cf.ac.uk/id/eprint/84817

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