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Expression analysis in a rat psychosis model identifies novel candidate genes validated in a large case?control sample of schizophrenia

Ingason, A, Giegling, I, Hartmann, A M, Genius, J, Konte, B, Friedl, M, Ripke, S, Sullivan, P F, St. Clair, D, Collier, D A, O'Donovan, Michael Conlon, Mirnics, K and Rujescu, D 2015. Expression analysis in a rat psychosis model identifies novel candidate genes validated in a large case?control sample of schizophrenia. Translational Psychiatry 5 (10) , e656. 10.1038/tp.2015.151

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Abstract

Antagonists of the N-methyl-D-aspartate (NMDA)-type glutamate receptor induce psychosis in healthy individuals and exacerbate schizophrenia symptoms in patients. In this study we have produced an animal model of NMDA receptor hypofunction by chronically treating rats with low doses of the NMDA receptor antagonist MK-801. Subsequently, we performed an expression study and identified 20 genes showing altered expression in the brain of these rats compared with untreated animals. We then explored whether the human orthologs of these genes are associated with schizophrenia in the largest schizophrenia genome-wide association study published to date, and found evidence for association for 4 out of the 20 genes: SF3B1, FOXP1, DLG2 and VGLL4. Interestingly, three of these genes, FOXP1, SF3B1 and DLG2, have previously been implicated in neurodevelopmental disorders.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: Nature Publishing Group
ISSN: 2158-3188
Date of Acceptance: 14 July 2015
Last Modified: 11 Jun 2019 14:33
URI: http://orca.cf.ac.uk/id/eprint/85024

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