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Hepatic tropism of adenoviral type 5 vectors can be mediated by multiple coagulation factors

Parker, Alan L., Nicol, Campbell G., Waddington, Simon N., Buckley, Suzanne M., Shayakhmetov, Dmitry M., Ni, Shaoheng H., Lieber, Andre, McVey, John H., Denby, Laura, Nicklin, Stuart A. and Baker, Andrew H. 2006. Hepatic tropism of adenoviral type 5 vectors can be mediated by multiple coagulation factors. Molecular Therapy 13 (S1) , S143-S143. 10.1016/j.ymthe.2006.08.436

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Abstract

A recent study demonstrated that Factor IX (FIX) directly binds the adenoviral (Ad) fibre knob domain |[ldquo]|bridging|[rdquo]| viral uptake into hepatocytes via heparan sulphate proteoglycans (HSPG) and/or low-density lipoprotein receptor related protein (LRP)1. In vivo, this phenomenon compensates for introduced capsid mutations abrogating CAR binding, accounting for the identical liver transduction levels of Ad5 vectors independent of CAR-binding status.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: Elsevier
ISSN: 1525-0016
Last Modified: 04 Jun 2017 08:48
URI: http://orca.cf.ac.uk/id/eprint/85166

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