Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

The ATXN1 and TRIM31 genes are related to intelligence in an ADHD background: evidence from a large collaborative study totaling 4,963 subjects

Rizzi, Thais S., Arias-Vasquez, Alejandro, Rommelse, Nanda, Kuntsi, Jonna, Anney, Richard, Asherson, Philip, Buitelaar, Jan, Banaschewski, Tobias, Ebstein, Richard, Ruano, Dina, Van der Sluis, Sophie, Markunas, Christina A., Garrett, Melanie E., Ashley-Koch, Allison E., Kollins, Scott H., Anastopoulos, Arthur D., Hansell, Narelle K., Wright, Margaret J., Montgomery, Grant W., Martin, Nicholas G., Harris, Sarah E., Davies, Gail, Tenesa, Albert, Porteous, David J., Starr, John M., Deary, Ian J., St Pourcain, Beate, Smith, George Davey, Timpson, Nicholas J., Evans, David M., Gill, Michael, Miranda, Ana, Mulas, Fernando, Oades, Robert D., Roeyers, Herbert, Rothenberger, Aribert, Sergeant, Joseph, Sonuga-Barke, Edmund J. S., Steinhausen, Hans Christoph, Taylor, Eric, Faraone, Stephen V., Franke, Barbara and Posthuma, Danielle 2011. The ATXN1 and TRIM31 genes are related to intelligence in an ADHD background: evidence from a large collaborative study totaling 4,963 subjects. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 156B (2) , pp. 145-157. 10.1002/ajmg.b.31149

Full text not available from this repository.

Abstract

Intelligence is a highly heritable trait for which it has proven difficult to identify the actual genes. In the past decade, five whole-genome linkage scans have suggested genomic regions important to human intelligence; however, so far none of the responsible genes or variants in those regions have been identified. Apart from these regions, a handful of candidate genes have been identified, although most of these are in need of replication. The recent growth in publicly available data sets that contain both whole genome association data and a wealth of phenotypic data, serves as an excellent resource for fine mapping and candidate gene replication. We used the publicly available data of 947 families participating in the International Multi-Centre ADHD Genetics (IMAGE) study to conduct an in silico fine mapping study of previously associated genomic locations, and to attempt replication of previously reported candidate genes for intelligence. Although this sample was ascertained for attention deficit/hyperactivity disorder (ADHD), intelligence quotient (IQ) scores were distributed normally. We tested 667 single nucleotide polymorphisms (SNPs) within 15 previously reported candidate genes for intelligence and 29451 SNPs in five genomic loci previously identified through whole genome linkage and association analyses. Significant SNPs were tested in four independent samples (4,357 subjects), one ascertained for ADHD, and three population-based samples. Associations between intelligence and SNPs in the ATXN1 and TRIM31 genes and in three genomic locations showed replicated association, but only in the samples ascertained for ADHD, suggesting that these genetic variants become particularly relevant to IQ on the background of a psychiatric disorder.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: genetic association;cognition;candidate genes;ADHD;ALSPAC
Publisher: Wiley-Blackwell
ISSN: 1552-485X
Last Modified: 04 Jun 2017 08:48
URI: http://orca.cf.ac.uk/id/eprint/85234

Citation Data

Cited 14 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item