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Autism symptoms in attention-deficit/hyperactivity disorder: a familial trait which correlates with conduct, oppositional defiant, language and motor disorders

Mulligan, Aisling, Anney, Richard, O'Regan, Myra, Chen, Wai, Butler, Louise, Fitzgerald, Michael, Buitelaar, Jan, Steinhausen, Hans-Christoph, Rothenberger, Aribert, Minderaa, Ruud, Nijmeijer, Judith, Hoekstra, Pieter J., Oades, Robert D., Roeyers, Herbert, Buschgens, Cathelijne, Christiansen, Hanna, Franke, Barbara, Gabriels, Isabel, Hartman, Catharina, Kuntsi, Jonna, Marco, Rafaela, Meidad, Sheera, Mueller, Ueli, Psychogiou, Lamprini, Rommelse, Nanda, Thompson, Margaret, Uebel, Henrik, Banaschewski, Tobias, Ebstein, Richard, Eisenberg, Jacques, Manor, Iris, Miranda, Ana, Mulas, Fernando, Sergeant, Joseph, Sonuga-Barke, Edmund J. S., Asherson, Phil, Faraone, Stephen V. and Gill, Michael 2009. Autism symptoms in attention-deficit/hyperactivity disorder: a familial trait which correlates with conduct, oppositional defiant, language and motor disorders. Journal of Autism and Developmental Disorders 39 (2) , pp. 197-209. 10.1007/s10803-008-0621-3

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Abstract

It is hypothesised that autism symptoms are present in Attention-Deficit/Hyperactivity Disorder (ADHD), are familial and index subtypes of ADHD. Autism symptoms were compared in 821 ADHD probands, 1050 siblings and 149 controls. Shared familiality of autism symptoms and ADHD was calculated using DeFries-Fulker analysis. Autism symptoms were higher in probands than siblings or controls, and higher in male siblings than male controls. Autism symptoms were familial, partly shared with familiality of ADHD in males. Latent class analysis using SCQ-score yielded five classes; Class 1(31%) had few autism symptoms and low comorbidity; Classes 2-4 were intermediate; Class 5(7%) had high autism symptoms and comorbidity. Thus autism symptoms in ADHD represent a familial trait associated with increased neurodevelopmental and oppositional/conduct disorders.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: ADHD Autism Familiality Oppositional disorders Motor disorder Language disorder
Publisher: Springer Verlag
ISSN: 0162-3257
Last Modified: 04 Jun 2017 08:48
URI: http://orca.cf.ac.uk/id/eprint/85254

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