Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Does Parental Expressed Emotion Moderate Genetic Effects in ADHD? An Exploration Using a Genome Wide Association Scan

Sonuga-Barke, Edmund J. S., Lasky-Su, Jessica, Neale, Benjamin M., Oades, Robert, Chen, Wai, Franke, Barbara, Buitelaar, Jan, Banaschewski, Tobias, Ebstein, Richard, Gill, Michael, Anney, Richard, Miranda, Ana, Mulas, Fernando, Roeyers, Herbert, Rothenberger, Aribert, Sergeant, Joseph, Steinhausen, Hans Christoph, Thompson, Margaret, Asherson, Philip and Faraone, Stephen V. 2008. Does Parental Expressed Emotion Moderate Genetic Effects in ADHD? An Exploration Using a Genome Wide Association Scan. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 147B (8) , pp. 1359-1368. 10.1002/ajmg.b.30860

Full text not available from this repository.

Abstract

Studies of gene × environment (G × E) interaction in ADHD have previously focused on known risk genes for ADHD and environmentally mediated biological risk. Here we use G × E analysis in the context of a genome-wide association scan to identify novel genes whose effects on ADHD symptoms and comorbid conduct disorder are moderated by high maternal expressed emotion (EE). SNPs (600,000) were genotyped in 958 ADHD proband-parent trios. After applying data cleaning procedures we examined 429,981 autosomal SNPs in 909 family trios. ADHD symptom severity and comorbid conduct disorder was measured using the Parental Account of Childhood Symptoms interview. Maternal criticism and warmth (i.e., EE) were coded by independent observers on comments made during the interview. No G × E interactions reached genome-wide significance. Nominal effects were found both with and without genetic main effects. For those with genetic main effects 36 uncorrected interaction P-values were <10−5 implicating both novel genes as well as some previously supported candidates. These were found equally often for all of the interactions being investigated. The observed interactions in SLC1A1 and NRG3 SNPs represent reasonable candidate genes for further investigation given their previous association with several psychiatric illnesses. We find evidence for the role of EE in moderating the effects of genes on ADHD severity and comorbid conduct disorder, implicating both novel and established candidates. These findings need replicating in larger independent samples.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: ADHD;gene-by-environment interaction;FBAT;genomewide association;hostility
Publisher: Wiley-Blackwell
ISSN: 1552-485X
Last Modified: 04 Jun 2017 08:48
URI: http://orca.cf.ac.uk/id/eprint/85262

Citation Data

Cited 60 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item