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Characterization of gastric mucosa biopsies reveals alterations in Huntington's Disease

McCourt, Andrew C, O'Donovan, Kirsty L, Ekblad, Eva, Sand, Elin, Craufurd, David, Rosser, Anne Elizabeth, Sanders, David, Stoy, Nicholas, Rickards, Hugh, Wierup, Nils, Bates, Gillian P., Björkqvist, Maria and Quarrell, Oliver 2015. Characterization of gastric mucosa biopsies reveals alterations in Huntington's Disease. PLoS Currents 1 10.1371/currents.hd.858b4cc7f235df068387e9c20c436a79

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Abstract

Weight loss is an important complication of Huntington's disease (HD), however the mechanism for weight loss in HD is not entirely understood. Mutant huntingtin is expressed in the gastrointestinal (GI) tract and, in HD mice, mutant huntingtin inclusions are found within the enteric nervous system along the GI tract. A reduction of neuropeptides, decreased mucosal thickness and villus length, as well as gut motility impairment, have also been shown in HD mice. We therefore set out to study gastric mucosa of patients with HD, looking for abnormalities of mucosal cells using immunohistochemistry. In order to investigate possible histological differences related to gastric acid production, we evaluated the cell density of acid producing parietal cells, as well as gastrin producing cells (the endocrine cell controlling parietal cell function). In addition, we looked at chief cells and somatostatin-containing cells. In gastric mucosa from HD subjects, compared to control subject biopsies, a reduced expression of gastrin (a marker of G cells) was found. This is in line with previous HD mouse studies showing reduction of GI tract neuropeptides.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Publisher: PLoS
ISSN: 2157-3999
Date of First Compliant Deposit: 30 March 2016
Last Modified: 12 Jun 2019 09:13
URI: http://orca.cf.ac.uk/id/eprint/85331

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