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The association between Darier disease, bipolar disorder, and schizophrenia revisited: a population-based family study

Cederlöf, Martin, Bergen, Sarah E, Långström, Niklas, Larsson, Henrik, Boman, Marcus, Craddock, Nicholas John, Östberg, Per, Lundström, Sebastian, Sjölander, Arvid, Nordlind, Klas, Landén, Mikael and Lichtenstein, Paul 2015. The association between Darier disease, bipolar disorder, and schizophrenia revisited: a population-based family study. Bipolar Disorders 17 (3) , pp. 340-344. 10.1111/bdi.12257

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Abstract

Objectives Darier disease is an autosomal dominant skin disorder caused by mutations in the ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (ATP2A2) gene and previously reported to cosegregate with bipolar disorder and schizophrenia in occasional pedigrees. It is, however, unknown whether these associations exist also in the general population, and the objective of this study was to examine this question. Methods We compared a national sample of individuals with Darier disease and their first-degree relatives with matched unexposed individuals from the general population and their first-degree relatives, respectively. To examine risks for bipolar disorder and schizophrenia, risk ratios and 95% confidence intervals (CIs) were estimated using conditional logistic regressions. Results Individuals with Darier disease had a 4.3 times higher risk of being diagnosed with bipolar disorder (95% CI: 2.6–7.3) and a 2.3 times higher risk of being diagnosed with schizophrenia (95% CI: 1.1–5.2) than matched individuals from the general population. Relatives of individuals with Darier disease had a 1.6 times higher risk of having bipolar disorder (95% CI: 1.1–2.5) than relatives of matched individuals from the general population, but no increased risk of schizophrenia (risk ratio = 0.8, 95% CI: 0.4–1.8). Conclusions The association between Darier disease and bipolar disorder is manifest also in the population, and our data suggest that genetic variability within the ATP2A2 gene that causes Darier disease also confers susceptibility for bipolar disorder. The Darier-causing mutations merit additional attention in molecular genetic research on bipolar disorder.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: bipolar disorder, Darier disease, epidemiology, schizophrenia
Publisher: Wiley
ISSN: 1398-5647
Date of Acceptance: 4 August 2014
Last Modified: 12 Jun 2019 09:59
URI: http://orca.cf.ac.uk/id/eprint/85591

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