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Functional connectivity pattern during rest within the episodic memory network in association with episodic memory performance in bipolar disorder

Oertel-Knöchel, Viola, Reinke, Britta, Matura, Silke, Prvulovic, David, Linden, David Edmund Johannes and Ven, Vincent van de 2015. Functional connectivity pattern during rest within the episodic memory network in association with episodic memory performance in bipolar disorder. Psychiatry Research: Neuroimaging 231 (2) , pp. 141-150. 10.1016/j.pscychresns.2014.11.014

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Abstract

In this study, we sought to examine the intrinsic functional organization of the episodic memory network during rest in bipolar disorder (BD). The previous work suggests that deficits in intrinsic functional connectivity may account for impaired memory performance. We hypothesized that regions involved in episodic memory processing would reveal aberrant functional connectivity in patients with bipolar disorder. We examined 21 patients with BD and 21 healthy matched controls who underwent functional magnetic resonance imaging (fMRI) during a resting condition. We did a seed-based functional connectivity analysis (SBA), using the regions of the episodic memory network that showed a significantly different activation pattern during task-related fMRI as seeds. The functional connectivity scores (FC) were further correlated with episodic memory task performance. Our results revealed decreased FC scores within frontal areas and between frontal and temporal/hippocampal/limbic regions in BD patients in comparison with controls. We observed higher FC in BD patients compared with controls between frontal and limbic regions. The decrease in fronto-frontal functional connectivity in BD patients showed a significant positive association with episodic memory performance. The association between task-independent dysfunctional frontal-limbic FC and episodic memory performance may be relevant for current pathophysiological models of the disease.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Resting state fMRI, Bipolar disorders, Frontal-limbic network
Publisher: Elsevier
ISSN: 0925-4927
Date of Acceptance: 21 November 2014
Last Modified: 04 Jun 2017 08:50
URI: http://orca.cf.ac.uk/id/eprint/85817

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