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CACNA1C risk variant is associated with increased amygdala volume

Lancaster, Thomas, Foley, Sonya, Tansey, Katherine E., Linden, David Edmund Johannes and Caseras, Xavier 2016. CACNA1C risk variant is associated with increased amygdala volume. European Archives of Psychiatry and Clinical Neuroscience 266 (3) , pp. 269-275. 10.1007/s00406-015-0609-x

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Abstract

Genome-wide association studies suggest that genetic variation within L-type calcium channel subunits confer risk to psychosis. The single nucleotide polymorphism at rs1006737 in CACNA1C has been associated with both schizophrenia and bipolar disorder and with several intermediate phenotypes that may serve as neurobiological antecedents, linking psychosis to genetic aetiology. Amongst others, it has been implicated in alterations in amygdala structure and function. In the present study, we show that the risk allele (A) is associated with increased amygdala volume in healthy individuals (n = 258). This observation reinforces a hypothesis that genetic variation may confer risk to psychosis via alterations in limbic structures. Further study of CACNA1C using intermediate phenotypes for psychosis will determine the mechanisms by which variation in this gene confers risk.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Bipolar, CACNA1C, Amygdala, rs1006737
Publisher: Springer
ISSN: 0940-1334
Date of Acceptance: 28 May 2015
Last Modified: 23 Feb 2018 10:04
URI: http://orca.cf.ac.uk/id/eprint/85864

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