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Timing of initiation, patterns of breastfeeding and infant survival: prospective analysis of pooled data from three randomised trials

Edmond, Karen, Newton, Sam, Hurt, Lisa, Shannon, Caitlin S., Kirkwood, Betty R., Mazumder, Sarmila, Taneja, Sunita, Bhandari, Nita, Fawzi, Wafaie, Honorati, Masanja, Smith, Emily R., Piwoz, Ellen, Bahl, Rajiv, Yoshida, Sachiyo and Martines, Jose Carlos 2016. Timing of initiation, patterns of breastfeeding and infant survival: prospective analysis of pooled data from three randomised trials. Lancet Global Health 4 (4) , e226-e275. 10.1016/S2214-109X(16)00040-1

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Abstract

Background: Initiation of breastfeeding within one hour of birth and exclusive breastfeeding for the first six months are currently recommended. The benefits of exclusive breastfeeding for child health and survival, particularly in the post-neonatal period, are established. The independent beneficial effect of early breastfeeding initiation remains unclear. Methods: We examined associations between timing of breastfeeding initiation, post-enrolment neonatal mortality (enrolment-28 days) and post-neonatal mortality up to six months of age (29-180 days) in a large cohort from three neonatal vitamin A trials in Ghana, India and Tanzania. Breastfeeding initiation was categorized as: at ≤1 hour, 2-23 hours, and 24-96 hours. Breastfeeding patterns were defined as exclusive, predominant or partial breastfeeding at four days, one month and three months of age. Relative risks were estimated using log binomial regression and Poisson regression with robust variances. Multivariate models controlled for site and potential confounders. Infants who initiated breastfeeding after 96 hours, did not initiate, or had missing initiation status were excluded. Results Of 99,938 enrolled infants, 57.0% initiated breastfeeding at ≤1 hour, 38.1% at 2-23 hours, and 4.6% at 24-96 hours. 306 infants who did not initiate breastfeeding by 96 hours age were excluded. Compared with infants initiating breastfeeding within the first hour of life, neonatal mortality between enrolment and 28 days was higher among infants initiating at 2-23 hours (adjusted relative risk=1.41 [95% Confidence Interval 1.24,1.62], p value <0.001), and among those initiating at 24-96 hours (1.79, [1.39, 2.30], p value <0.001). These relationships were not different when deaths in the first four days of life were excluded, or when data were stratified by exclusive breastfeeding status at four days of age (p value for interaction=0.690). Exclusive breastfeeding was associated with lower post-enrolment neonatal mortality, and both early breastfeeding initiation and exclusive breastfeeding were associated with lower mortality between 29 and 180 days. Conclusions Our findings suggest that early initiation of breastfeeding reduces neonatal and early infant mortality both through increasing rates of exclusive breastfeeding and by additional mechanisms. Both practices should be promoted by public health programmes and should be used in models to estimate lives saved.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services
Additional Information: Pdf uploaded in accordance with publisher's policy at http://www.sherpa.ac.uk/romeo/issn/2214-109X/ (accessed 03/02/2016)
Publisher: Elsevier
ISSN: 2214-109X
Funders: Gates Foundation
Date of First Compliant Deposit: 30 March 2016
Date of Acceptance: 20 January 2016
Last Modified: 17 Jun 2019 10:03
URI: http://orca.cf.ac.uk/id/eprint/86245

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