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An Overview of measuring impulsive behavior in mice

Dent, Claire L and Isles, Anthony Roger 2014. An Overview of measuring impulsive behavior in mice. Current Protocols in Mouse Biology 4 (2) , pp. 35-45. 10.1002/9780470942390.mo140015

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Abstract

Impulsive behavior is a key constituent of many psychiatric illnesses, with maladaptive response control being a feature of disorders such as ADHD, schizophrenia, mania, and addiction. In order to understand the neurological underpinnings of impulsivity, a number of behavioral tasks have been developed for use with animal models. Data from studies with rats and other animals have led to the idea of the existence of dissociable components of impulsivity, which in turn informs studies of human disorders and potentially the development of specific therapies. Increasingly, mouse models are being used to investigate the known genetic contribution to psychiatric disorders in which abnormal response control leads to altered impulsive behaviors. In order to maximize the potential of these mouse models, it is important that researchers take into account the non-unitary nature of response control and impulsivity. In this article, we briefly review the tasks available to behavioral neuroscientists and how these can be used in order to tease apart the contribution of a specific genetic lesion into the discrete aspects of impulsive behavior.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Neuroscience and Mental Health Research Institute (NMHRI)
Psychology
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: action impulsivity;choice impulsivity;operant;psychiatric genetics
Publisher: Wiley
ISSN: 2161-2617
Funders: Leverhulme Trust
Last Modified: 31 May 2019 13:43
URI: http://orca.cf.ac.uk/id/eprint/86613

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