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Anti-flavivirus activity of different tritylated pyrimidine and purine nucleoside analogues

McGuigan, Christopher, Serpi, Michaela, Slusarczyk, Magdalena, Ferrari, Valentina, Pertusati, Fabrizio, Meneghesso, Silvia, Derudas, Marco, Farleigh, Laura, Zanetta, Paola and Bugert, Joachim Jakob 2016. Anti-flavivirus activity of different tritylated pyrimidine and purine nucleoside analogues. ChemistryOpen 5 (3) , pp. 227-235. 10.1002/open.201500216

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Abstract

A series of tritylated and dimethoxytritylated analogues of selected pyrimidine and purine nucleosides were synthesized and evaluated for their in vitro inhibitory activity against two important members of the genus Flavivirus in the Flaviviridae family, the yellow fever (YFV) and dengue viruses (DENV). Among all compounds tested, the 5’-O-tritylated and the 5’-Odimethoxytritylated 5-fluorouridine derivatives exerted potency against YFV. Interestingly in the series of purine analogues, the 5’O, N-bis-tritylated fludarabine derivative revealed strong inhibitory activity against DENV at mm concentrations, however significantly weaker potency against YFV.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > RM Therapeutics. Pharmacology
Additional Information: Article first published online: 21 JAN 2016 This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License
Publisher: Wiley-VCH
ISSN: 2191-1363
Date of First Compliant Deposit: 30 March 2016
Date of Acceptance: 19 November 2015
Last Modified: 24 Oct 2018 22:23
URI: http://orca.cf.ac.uk/id/eprint/86634

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