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Gamma-secretase regulates VEGFR-1 signalling in vascular endothelium and RPE

Boulton, Michael, Cai, Jun, Grant, Maria B. and Zhang, Yadan 2008. Gamma-secretase regulates VEGFR-1 signalling in vascular endothelium and RPE. Advances in Experimental Medicine and Biology 613 , pp. 313-319. 10.1007/978-0-387-74904-4_36

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In conclusion, gamma-secretase is expressed in both retinal microvascular endothelial cells and RPE cells and is able to elicit regulated intramembrane proteolysis of VEGFR1. Furthermore, gamma-secretase regulates the translocation of the intracellular domain of VEGFR1 as well as full length VEGFR1 in both cell types. Gamma-secretase is clearly able to act as a potent negative regulators of VEGFR2 induced in vitro angiogenesis but its role in the RPE has yet to be elucidated. We conclude that gamma-secretase may offer a therapeutic target for the treatment of both retinal and choroidal neovascularization.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: Springer
ISSN: 0065-2598
Last Modified: 04 Jun 2017 08:53

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