Meier, Samuel M., Gerner, Christopher, Keppler, Bernhard K., Cinellu, Maria Agostina and Casini, Angela ORCID: https://orcid.org/0000-0003-1599-9542 2016. Mass spectrometry uncovers molecular reactivities of coordination and organometallic gold (III) drug candidates in competitive experiments that correlate with their biological effects. Inorganic Chemistry 55 (9) , pp. 4248-4259. 10.1021/acs.inorgchem.5b03000 |
Official URL: http://dx.doi.org/10.1021/acs.inorgchem.5b03000
Abstract
Mass spectrometry reveals profound differences in the reactivity of coordinative and organometallic gold(III) drug candidates to bionucleophiles, which impact their proposed modes of action targeting the selenoenzyme thioredoxin reductase. This provides a link between molecular reactivity and biological activity in vitro.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Chemistry |
Subjects: | Q Science > QD Chemistry |
Publisher: | American Chemical Society |
ISSN: | 0020-1669 |
Last Modified: | 31 Oct 2022 11:00 |
URI: | https://orca.cardiff.ac.uk/id/eprint/87033 |
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