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New luminescent polynuclear metal complexes with anticancer properties: toward structure-activity relationships

Wenzel, Margot, De Almeida, Andreia, Bigaeva, Emilia, Kavanagh, Paul, Picquet, Michel, Le Gendre, Pierre, Bodio, Ewen and Casini, Angela 2016. New luminescent polynuclear metal complexes with anticancer properties: toward structure-activity relationships. Inorganic Chemistry 55 (5) , pp. 2544-2557. 10.1021/acs.inorgchem.5b02910

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Abstract

A series of heterodinuclear complexes exhibiting both luminescent and anticancer properties is described. The photophysical and electrochemical characteristics and antiproliferative properties against cancer cells of the compounds have been reported, as well as the exploration of the possible interaction with DNA. Exploration of the mechanism of uptake of the complexes inside cells has been investigated using fluorescence microscopy and glucose transporter inhibition experiments.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Publisher: American Chemical Society
ISSN: 0020-1669
Last Modified: 16 May 2019 12:55
URI: http://orca.cf.ac.uk/id/eprint/87034

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