Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Molecular characterization of carbapenemase-producing Escherichia coli and Klebsiella pneumoniae in the countries of the Gulf cooperation council: dominance of OXA-48 and NDM producers.

Zowawi, Hosam M., Sartor, Anna L., Balkhy, Hanan H., Walsh, Timothy Rutland, Al Johani, Sameera M., AlJindan, Reem Y., Alfaresi, Mubarak, Ibrahim, Emad, Al-Jardani, Amina, Al-Abri, Seif, Al Salman, Jameela, Dashti, Ali A., Kutbi, Abdullah H., Schlebusch, Sanmarie, Sidjabat, Hanna E. and Paterson, David L. 2014. Molecular characterization of carbapenemase-producing Escherichia coli and Klebsiella pneumoniae in the countries of the Gulf cooperation council: dominance of OXA-48 and NDM producers. Antimicrobial Agents and Chemotherapy 58 (6) , pp. 3085-3090. 10.1128/AAC.02050-13

Full text not available from this repository.

Abstract

The molecular epidemiology and mechanisms of resistance of carbapenem-resistant Enterobacteriaceae (CRE) were determined in hospitals in the countries of the Gulf Cooperation Council (GCC), namely, Saudi Arabia, United Arab Emirates, Oman, Qatar, Bahrain, and Kuwait. Isolates were subjected to PCR-based detection of antibiotic-resistant genes and repetitive sequence-based PCR (rep-PCR) assessments of clonality. Sixty-two isolates which screened positive for potential carbapenemase production were assessed, and 45 were found to produce carbapenemase. The most common carbapenemases were of the OXA-48 (35 isolates) and NDM (16 isolates) types; 6 isolates were found to coproduce the OXA-48 and NDM types. No KPC-type, VIM-type, or IMP-type producers were detected. Multiple clones were detected with seven clusters of clonally related Klebsiella pneumoniae. Awareness of CRE in GCC countries has important implications for controlling the spread of CRE in the Middle East and in hospitals accommodating patients transferred from the region.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: American Society for Microbiology
ISSN: 0066-4804
Last Modified: 07 Feb 2019 11:29
URI: http://orca.cf.ac.uk/id/eprint/87627

Citation Data

Cited 65 times in Scopus. View in Scopus. Powered By Scopus® Data

Cited 19 times in Web of Science. View in Web of Science.

Actions (repository staff only)

Edit Item Edit Item