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Time course of changes in tear meniscus radius and blink rate after instillation of artificial tears

Bandlitz, Stefan, Purslow, Christine, Murphy, Paul J. and Pult, Heiko 2014. Time course of changes in tear meniscus radius and blink rate after instillation of artificial tears. Investigative Ophthalmology and Visual Science 55 (9) , pp. 5842-5847. 10.1167/iovs.14-14844.

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Abstract

PURPOSE: Using a novel digital meniscometer (PDM), alterations in tear meniscus radius (TMR) were measured simultaneously with blink rate (BR) following the instillation of artificial tears. METHODS: Central TMR and BR of 22 subjects (11 male and 11 female; mean age, 24.3 ± 2.6 SD years) were measured at baseline, and 0, 1, 5, 10, and 30 minutes after instillation of an artificial tear containing hydroxypropyl-guar and glycol (SYS) or saline (SAL). A dose of 35 μL was applied in one eye in a randomized order with a washout period between each drop. RESULTS: For SAL, compared to baseline TMR (0.33 ± 0.08 mm), TMR significantly increased with drop instillation (1.55 ± 0.69 mm) and at 1 minute (0.66 ± 0.36 mm; P < 0.05), but returned to baseline after 5 minutes. For SYS, TMR (0.32 ± 0.07 mm) remained significantly increased after application (1.62 ± 0.81 mm), and at 1 minute (0.81 ± 0.43 mm) and 5 minutes (0.39 ± 0.08 mm; P < 0.05). Compared to baseline BR with SAL (14.8 ± 7.7) and SYS (14.9 ± 9.4), values were significantly increased upon drop instillation (22.5 ± 11.8; 21.3 ± 11.8; P < 0.05), but returned to baseline after 1 minute. Dry eye symptoms were correlated with baseline BR (r = 0.550, P = 0.008). CONCLUSIONS: Results indicate that PDM can detect changes in TMR following instillation of artificial tears. Difference in residence time reflects the different viscosity of each drop. An overload with a large drop may result in an initially increased BR.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Optometry and Vision Sciences
Subjects: R Medicine > RE Ophthalmology
Uncontrolled Keywords: artificial tears; blink rate; dry eye symptoms; portable digital meniscometer; tear meniscus; tear volume loss
Publisher: Association for Research in Vision and Ophthalmology
ISSN: 0146-0404
Last Modified: 23 Apr 2019 21:20
URI: http://orca.cf.ac.uk/id/eprint/87803

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