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Epithelial-mesenchymal transition and the use of ECIS

Lane, Jane and Jiang, Wen Guo 2012. Epithelial-mesenchymal transition and the use of ECIS. In: Jiang, Wen Guo ed. Electric Cell-Substrate Impedance Sensing and Cancer Metastasis, Vol. 17. Cancer Metastasis - Biology and Treatment, Dordrecht: Springer Science+Business Media, pp. 71-84. (10.1007/978-94-007-4927-6_5)

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Abstract

The development of tumour cell invasion and metastasis is a prime factor influencing prognosis of cancer patients. Understanding the mechanisms involved in tumour cell invasion may aid in limiting tumour progression and lead to a reduction in patient mortality. In order to become invasive, tumour cells must overcome the physical barriers imposed by cell–cell adhesions and the basement membrane and attain a motile phenotype. Evidence is emerging which indicates a role for epithelial–mesenchymal transition (EMT) in tumour cell invasion whereby tumour cells would lose E-cadherin-dependent intercellular adhesion and acquire the ability to migrate, enabling these cells to invade adjacent tissues. This current chapter reviews the role of EMT in cancer metastasis and looks at the Electrical Cell-substrate Impedance Sensing system (ECIS) as an important tool for analysing changes in cell motility.

Item Type: Book Section
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Publisher: Springer Science+Business Media
ISBN: 9789400749269
Funders: Cancer Research Wales, Breast Cancer Hope Foundation
Last Modified: 23 Apr 2019 21:23
URI: http://orca.cf.ac.uk/id/eprint/87924

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