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Scaling-down antibody radiolabeling reactions with zirconium-89

Knight, James C., Paisey, Stephen James, Dabkowski, Adam M., Marculescu, Cristina, Williams, Anwen Sian, Marshall, Christopher and Cornelissen, Bart 2016. Scaling-down antibody radiolabeling reactions with zirconium-89. Dalton Transactions 45 (15) , pp. 6343-6347. 10.1039/C5DT04774A

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Abstract

The most widely cited procedures for radiolabeling antibodies with zirconium-89 for immuno-PET require multi-milligram amounts of antibody which can be cost-prohibitive, particularly during the research and development process. We therefore sought to develop a reliable 89Zr-radiolabeling procedure that provides high radiochemical yields at the microgram scale.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: Royal Society of Chemistry
ISSN: 1477-9226
Date of Acceptance: 7 March 2016
Last Modified: 26 Dec 2017 20:56
URI: http://orca.cf.ac.uk/id/eprint/88047

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