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Quality of life impact of childhood skin conditions measured using the Children's Dermatology Life Quality Index (CDLQI): a meta-analysis

Olsen, J. R., Gallacher, J., Finlay, Andrew Yule, Piguet, Vincent and Francis, Nicholas Andrew 2016. Quality of life impact of childhood skin conditions measured using the Children's Dermatology Life Quality Index (CDLQI): a meta-analysis. British Journal of Dermatology 174 (4) , pp. 853-861. 10.1111/bjd.14361

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Abstract

Summary Background The Children's Dermatology Life Quality Index (CDLQI) is the most widely used instrument for measuring the impact of skin disease on quality of life (QoL) in children. Objectives To provide a meta-analysis of all published QoL scores for a range of childhood skin conditions. Methods Studies using the CDLQI questionnaire to measure QoL in skin conditions were identified by searching Medline and Embase from January 1995 (CDLQI creation) to December 2014. Studies were grouped according to condition and baseline scores were combined using meta-analysis. Results Sixty-seven studies using the CDLQI met the inclusion criteria. The overall estimated CDLQI scores for conditions reported more than once were [point estimate (95% confidence interval, CI), number of studies (n), score range]: atopic eczema [8·5 (7·1–9·8), n = 38, 0–29], acne [5·3 (1·9–8·5), n = 5, 0–30], alopecia [3·1 (0–7·7), n = 2, 0–6], molluscum contagiosum [3·5 (0·6–6·7), n = 5, 0–27], psoriasis [8·0 (3·9–12·1), n = 6, 0–29], scabies [9·2 (0·0–20·3), n = 2, 1–26], urticaria [7·1 (0–15·4), n = 2, 0–22], vitiligo [6·5 (0·7–12·2), n = 2, 0–20] and warts [2·9 (0–5·8), n = 4, 0–16]. Overall, the mean effect on QoL [weighted average CDLQI score 4·6 (95% CI 3·9–5·4)] for children with these conditions was small. However, many children were found to experience a very large impact on QoL (34% of children with atopic eczema, 10% with molluscum contagiosum and 1–5% with acne) in studies where the distributions of scores were provided. Conclusions Most skin conditions in children have a ‘small’ mean effect on QoL. However, the range is large and a significant proportion of children with many common skin conditions will experience a very large effect on quality of life.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: Wiley-Blackwell
ISSN: 0007-0963
Date of Acceptance: 30 November 2015
Last Modified: 23 Apr 2019 21:26
URI: http://orca.cf.ac.uk/id/eprint/88063

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