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Expression of death receptor-3 in human breast cancer and its functional effects on breast cancer cells in vitro

Ge, Z., Sanders, Andrew J., Ye, Lin, Mansel, Robert E. and Jiang, Wen Guo 2013. Expression of death receptor-3 in human breast cancer and its functional effects on breast cancer cells in vitro. Oncology Reports 29 , pp. 1356-1364. 10.3892/or.2013.2259

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Abstract

Death receptor-3 (DR3) plays controversial roles in cancer. Currently, DR3 is known to be a functional receptor of vascular endothelial growth inhibitor (VEGI). The role of DR3 in breast cancer remains unclear. The present study investigated DR3 expression in a clinical cohort of breast cancer patients and its role in breast cancer cells in vitro. The expression of DR3 was examined in a breast cancer cohort using quantitative PCR (Q-PCR) and immunohistochemistry (IHC) in comparison to the patients' data. In vitro function of DR3 was examined through the targeting of this molecule in MCF7 and MDA-MB-231 breast cancer cells using ribozyme transgene technology. Decreased DR3 expression was noted in breast cancer tissues compared to normal tissues and decreased expression of DR3 was generally associated with a poorer prognosis as well as a significantly shorter long-term survival (p=0.038). Targeting of DR3 in vitro in breast cancer cell lines resulted in impaired migratory rates compared to respective control cells. Collectively, these data suggest a complex role for DR3 in breast cancer development and progression.

Item Type: Article
Status: Published
Schools: Medicine
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Publisher: Spandidos Publications
Last Modified: 04 Jun 2017 08:57
URI: http://orca.cf.ac.uk/id/eprint/88369

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