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Functionalized α-helical peptide hydrogels for neural tissue engineering

Mehrban, Nazia, Zhu, Bangfu, Tamagnini, Francesco, Young, Fraser, Wasmuth, Alexandra, Hudson, Kieran L., Thomson, Andrew R., Birchall, Martin A., Randall, Andrew D., Song, Bing and Woolfson, Derek N. 2015. Functionalized α-helical peptide hydrogels for neural tissue engineering. ACS Biomaterials Science & Engineering 1 (6) , pp. 431-439. 10.1021/acsbiomaterials.5b00051

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Abstract

Trauma to the central and peripheral nervous systems often lead to serious morbidity. Current surgical methods for repairing or replacing such damage have limitations. Tissue engineering offers a potential alternative. Here we show that functionalized α-helical-peptide hydrogels can be used to induce attachment, migration, proliferation and differentiation of murine embryonic neural stem cells (NSCs). Specifically, compared with undecorated gels, those functionalized with Arg-Gly-Asp-Ser (RGDS) peptides increase the proliferative activity of NSCs; promote their directional migration; induce differentiation, with increased expression of microtubule-associated protein-2, and a low expression of glial fibrillary acidic protein; and lead to the formation of larger neurospheres. Electrophysiological measurements from NSCs grown in RGDS-decorated gels indicate developmental progress toward mature neuron-like behavior. Our data indicate that these functional peptide hydrogels may go some way toward overcoming the limitations of current approaches to nerve-tissue repair.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Dentistry
Additional Information: The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acsbiomaterials.5b00051.
Publisher: ACS Publications
ISSN: 2373-9878
Last Modified: 05 Aug 2019 12:58
URI: http://orca.cf.ac.uk/id/eprint/88468

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