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Acute myeloid leucaemia presenting as a rapidly progressive polyradiculoneuropathy

Hirst, C. L., Willis, Mark, Hussain, H. and Powell, R. 2015. Acute myeloid leucaemia presenting as a rapidly progressive polyradiculoneuropathy. BMJ Case Reports 2015 , bcr2015209556. 10.1136/bcr-2015-209556

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Abstract

Neurological involvement at onset in acute myeloid leucaemia (AML) is rare, with only a few isolated case reports. We present the case of a 46-year-old man with rapidly progressive polyradiculoneuropathy as the presenting feature of AML. The proposed mechanism for this is postulated to be direct intraneural infiltration, although a paraneoplastic, autoimmune-related phenomenon could be possible. Despite chemotherapeutic intervention, the patient died 1 month after initial presentation. Although rare, neurological manifestations of AML do occur and it is important to include haematological malignancies in the differential diagnosis in patients presenting with neurological symptoms.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: BMJ Publishing Group Ltd
ISSN: 1757-790X
Date of Acceptance: 31 October 2015
Last Modified: 13 Jun 2019 12:56
URI: http://orca.cf.ac.uk/id/eprint/88645

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