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Cluster of atypical adult Guillain-Barré syndrome temporally associated with neurological illness due to EV-D68 in children, South Wales, United Kingdom, October 2015 to January 2016

Williams, Christopher J, Thomas, Rhys Huw, Pickersgill, Trevor P, Lyons, Marion, Lowe, Gwen, Stiff, Rhianwen E, Moore, Catherine, Jones, Rachel, Howe, Robin, Brunt, Huw, Ashman, Anna and Mason, Brendan W 2016. Cluster of atypical adult Guillain-Barré syndrome temporally associated with neurological illness due to EV-D68 in children, South Wales, United Kingdom, October 2015 to January 2016. Eurosurveillance 21 (4) , 30119. 10.2807/1560-7917.ES.2016.21.4.30119

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Abstract

We report a cluster of atypical Guillain-Barré syndrome in 10 adults temporally related to a cluster of four children with acute flaccid paralysis, over a 3-month period in South Wales, United Kingdom. All adult cases were male, aged between 24 and 77 years. Seven had prominent facial diplegia at onset. Available electrophysiological studies showed axonal involvement in five adults. Seven reported various forms of respiratory disease before onset of neurological symptoms. The ages of children ranged from one to 13 years, three of the four were two years old or younger. Enterovirus testing is available for three children; two had evidence of enterovirus D68 infection in stool or respiratory samples. We describe the clinical features, epidemiology and state of current investigations for these unusual clusters of illness.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: European Centre for Disease Prevention and Control
ISSN: 1025-496X
Date of Acceptance: 28 January 2016
Last Modified: 17 Jun 2019 13:08
URI: http://orca.cf.ac.uk/id/eprint/88688

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