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Simple and versatile 3D printed microfluidics using fused filament fabrication

Morgan, Alex John, Hidalgo San Jose, Lorena, Jamieson, William David, Wymant, Jennifer, Song, Bing, Stephens, Philip, Barrow, David Anthony and Castell, Oliver Kieran 2016. Simple and versatile 3D printed microfluidics using fused filament fabrication. PLoS ONE 11 (4) , e0152023. 10.1371/journal.pone.0152023

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Abstract

The uptake of microfluidics by the wider scientific community has been limited by the fabrication barrier created by the skills and equipment required for the production of traditional microfluidic devices. Here we present simple 3D printed microfluidic devices using an inexpensive and readily accessible printer with commercially available printer materials. We demonstrate that previously reported limitations of transparency and fidelity have been overcome, whilst devices capable of operating at pressures in excess of 2000 kPa illustrate that leakage issues have also been resolved. The utility of the 3D printed microfluidic devices is illustrated by encapsulating dental pulp stem cells within alginate droplets; cell viability assays show the vast majority of cells remain live, and device transparency is sufficient for single cell imaging. The accessibility of these devices is further enhanced through fabrication of integrated ports and by the introduction of a Lego®-like modular system facilitating rapid prototyping whilst offering the potential for novices to build microfluidic systems from a database of microfluidic components.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Dentistry
Engineering
Pharmacy
Publisher: Public Library of Science
ISSN: 1932-6203
Date of First Compliant Deposit: 13 April 2016
Date of Acceptance: 7 March 2016
Last Modified: 23 Jun 2019 21:36
URI: http://orca.cf.ac.uk/id/eprint/89184

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Cited 49 times in Scopus. View in Scopus. Powered By Scopus® Data

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