Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Abrogation of the interferon response promotes more efficient human cytomegalovirus replication

McSharry, Brian P., Forbes, Simone K., Avdic, Selmir, Randall, Richard E., Wilkinson, Gavin, Abendroth, Allison, Slobedman, Barry and Hutt-Fletcher, L. 2015. Abrogation of the interferon response promotes more efficient human cytomegalovirus replication. Journal of Virology 89 (2) , pp. 1479-1483. 10.1128/JVI.02988-14

Full text not available from this repository.

Abstract

The effect of abrogating the interferon (IFN) response on human cytomegalovirus (HCMV) replication was investigated using primary human cells engineered to block either the production of or the response to type I IFNs. In IFN-deficient cells, HCMV produced larger plaques and spread and replicated more rapidly than in parental cells. These cells demonstrate the vital role of IFNs in controlling HCMV replication and provide useful tools to investigate the IFN response to HCMV.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > RB Pathology
Publisher: American Society for Microbiology
ISSN: 0022538X
Date of Acceptance: 4 November 2014
Last Modified: 04 Jun 2017 09:00
URI: http://orca.cf.ac.uk/id/eprint/89276

Citation Data

Cited 9 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item