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Abrogation of the interferon response promotes more efficient human cytomegalovirus replication

McSharry, Brian P., Forbes, Simone K., Avdic, Selmir, Randall, Richard E., Wilkinson, Gavin ORCID: https://orcid.org/0000-0002-5623-0126, Abendroth, Allison, Slobedman, Barry and Hutt-Fletcher, L. 2015. Abrogation of the interferon response promotes more efficient human cytomegalovirus replication. Journal of Virology 89 (2) , pp. 1479-1483. 10.1128/JVI.02988-14

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Abstract

The effect of abrogating the interferon (IFN) response on human cytomegalovirus (HCMV) replication was investigated using primary human cells engineered to block either the production of or the response to type I IFNs. In IFN-deficient cells, HCMV produced larger plaques and spread and replicated more rapidly than in parental cells. These cells demonstrate the vital role of IFNs in controlling HCMV replication and provide useful tools to investigate the IFN response to HCMV.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > RB Pathology
Publisher: American Society for Microbiology
ISSN: 0022-538X
Date of Acceptance: 4 November 2014
Last Modified: 01 Nov 2022 09:48
URI: https://orca.cardiff.ac.uk/id/eprint/89276

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