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Impact of non-alcoholic fatty liver disease on liver volume in humans

Bian, Hua, Hakkarainen, Antti, Zhou, You, Lundbom, Nina, Olkkonen, Vesa M and Yki-Järvinen, Hannele 2015. Impact of non-alcoholic fatty liver disease on liver volume in humans. Hepatology Research 45 (2) , pp. 210-219. 10.1111/hepr.12338

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Abstract

Aim Knowledge of liver volume is needed in the preoperative screening of liver transplant donors and in pharmacokinetic studies. In previous studies, bodyweight, surface area, age and sex have been identified as predictors of total liver volume, but the impact of non-alcoholic fatty liver disease (NAFLD) independent of body size on liver volume has not been determined. We examined whether and to what extent liver fat due to NAFLD influences liver volume. Methods We quantified the percentage of liver fat by proton magnetic resonance spectroscopy (1H-MRS) and liver total, lean and fat volumes using magnetic resonance imaging (MRI) in 112 subjects (62 women, 50 men), who were characterized with respect to metabolic parameters associated with NAFLD. Results Of the subjects, 45% had NAFLD (liver fat 12.5 ± 4.5% vs 1.8 ± 1.6%, NAFLD vs no NAFLD, P < 0.001). Total liver volume was 29% higher in subjects with NAFLD (1.91 ± 0.45 L) than in those with no NAFLD (1.49 ± 0.31 L, P < 0.001). In multiple linear regression analysis, the percentage of liver fat and bodyweight independently explained variation in total liver volume (r2 = 0.42, P < 0.001). The r-values for the relationship between metabolic parameters and the total liver fat volume were not significantly better than those between metabolic parameters and the percentage of liver fat. Conclusion Both bodyweight and NAFLD increase liver volume independent of each other. Measurement of liver fat by 1H-MRS allows accurate quantification of NAFLD and calculation of total liver volume.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: Q Science > QR Microbiology > QR180 Immunology
Publisher: Wiley-Blackwell
ISSN: 1386-6346
Date of Acceptance: 31 March 2014
Last Modified: 04 Jun 2017 09:03
URI: http://orca.cf.ac.uk/id/eprint/89819

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