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Laminar analysis of the role of GluR1 in experience-dependent and synaptic depression in barrel cortex

Wright, Nicholas Fraser, Glazewski, Stanislaw, Hardingham, Neil Robert, Phillips, Keith, Pervolaraki, Eleftheria and Fox, Kevin Dyson 2008. Laminar analysis of the role of GluR1 in experience-dependent and synaptic depression in barrel cortex. Nature Neuroscience 11 (10) , pp. 1140-1142. 10.1038/nn.2188

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Abstract

Several synaptic depression mechanisms have been described for the hippocampus, cerebellum and neocortex in vitro, but little is known about which, if any, are engaged during experience-dependent depression (EDD). We found that EDD in the mouse barrel cortex depends on the AMPA subunit GluR1 in layers II/III and IV, but not in layer V, and that long-term depression is also GluR1 dependent in the IV-II/III, but not II/III–V, pathway.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Psychology
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: Nature Publishing Group
ISSN: 1097-6256
Last Modified: 03 Jun 2019 19:21
URI: http://orca.cf.ac.uk/id/eprint/8989

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