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AIDS virus-specific CD8+T lymphocytes against an immunodominant cryptic epitope select for viral escape

Maness, Nicholas J., Valentine, Laura E., May, Gemma E., Reed, Jason, Piaskowski, Shari M., Soma, Taeko, Furlott, Jessica, Rakasz, Eva G., Friedrich, Thomas C., Price, David, Gostick, Emma, Hughes, Austin L., Sidney, John, Sette, Alessandro, Wilson, Nancy A. and Watkins, David I. 2007. AIDS virus-specific CD8+T lymphocytes against an immunodominant cryptic epitope select for viral escape. Journal of Experimental Medicine 204 (11) , pp. 2505-2512. 10.1084/jem.20071261

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Abstract

Cryptic major histocompatibility complex class I epitopes have been detected in several pathogens, but their importance in the immune response to AIDS viruses remains unknown. Here, we show that Mamu-B*17+ simian immunodeficiency virus (SIV)mac239-infected rhesus macaques that spontaneously controlled viral replication consistently made strong CD8+ T lymphocyte (CD8-TL) responses against a cryptic epitope, RHLAFKCLW (cRW9). Importantly, cRW9-specific CD8-TL selected for viral variation in vivo and effectively suppressed SIV replication in vitro, suggesting that they might play a key role in the SIV-specific response. The discovery of an immunodominant CD8-TL response in elite controller macaques against a cryptic epitope suggests that the AIDS virus–specific cellular immune response is likely far more complex than is generally assumed.

Item Type: Article
Status: Published
Schools: Medicine
Subjects: Q Science > QR Microbiology > QR180 Immunology
Q Science > QR Microbiology > QR355 Virology
Additional Information: Publisher's PDF uploaded in accordance with policy at http://www.sherpa.ac.uk/romeo/issn/0022-1007/ [accessed 22/06/2016]
Publisher: Rockefeller University Press
ISSN: 0022-1007
Date of First Compliant Deposit: 25 April 2016
Date of Acceptance: 25 September 2007
Last Modified: 04 Jun 2017 09:03
URI: http://orca.cf.ac.uk/id/eprint/89922

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