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Cd8+ T cells from siv elite controller macaques recognize mamu-b*08-bound epitopes and select for widespread viral variation

Loffredo, John T., Friedrich, Thomas C., León, Enrique J., Stephany, Jason J., Rodrigues, Denise S., Spencer, Sean P., Bean, Alex T., Beal, Dominic R., Burwitz, Benjamin J., Rudersdorf, Richard A., Wallace, Lyle T., Piaskowski, Shari M., May, Gemma E., Sidney, John, Gostick, Emma, Wilson, Nancy A., Price, David, Kallas, Esper G., Piontkivska, Helen, Hughes, Austin L., Sette, Alessandro and Watkins, David I. 2007. Cd8+ T cells from siv elite controller macaques recognize mamu-b*08-bound epitopes and select for widespread viral variation. PLoS ONE 2 (11) , e1152. 10.1371/journal.pone.0001152

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Abstract

It is generally accepted that CD8+ T cell responses play an important role in control of immunodeficiency virus replication. The association of HLA-B27 and -B57 with control of viremia supports this conclusion. However, specific correlates of viral control in individuals expressing these alleles have been difficult to define. We recently reported that transient in vivo CD8+ cell depletion in simian immunodeficiency virus (SIV)-infected elite controller (EC) macaques resulted in a brief period of viral recrudescence. SIV replication was rapidly controlled with the reappearance of CD8+ cells, implicating that these cells actively suppress viral replication in ECs.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Public Library of Science
ISSN: 1932-6203
Date of First Compliant Deposit: 25 April 2016
Date of Acceptance: 12 October 2007
Last Modified: 04 Jun 2017 09:03
URI: http://orca.cf.ac.uk/id/eprint/89925

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