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The impact of breast size on mean lung dose for patients receiving tangential radiotherapy to the whole breast

Schembri, Ashley, Mercieca, Susan, Courtier, Nicholas and Zarb, Francis 2016. The impact of breast size on mean lung dose for patients receiving tangential radiotherapy to the whole breast. Journal of Radiotherapy in Practice 15 (2) , pp. 181-188. 10.1017/S1460396916000091

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Abstract

Purpose To explore the impact of breast size on mean lung dose (MLD) for patients receiving breast radiotherapy. Methodology Chest wall separation (CWS), volume of tissue receiving 95% isodose and MLD were measured on 80 radiotherapy treatment plans of patients receiving tangential radiotherapy treatment to the whole breast. Breast size was categorised as small (CWS<25 cm and planned target volume (PTV)<1,500 cm3) and large (CWS>25 cm and PTV>1500 cm3). Pearson’s correlation and independent sample t-test were used to analyse data. Results MLD was not affected by CWS (r=−0·13, p=0·24) nor volume of tissue receiving 95% isodose (r=−0·08, p=0·49). Significant variation between small and large breasts was noted for CWS (t=8·24, p=0·00) and volume of tissue receiving 95% isodose (t=5·68, p=0·00). No significant variation was noted between small and large breast for MLD (t=−0·26, p=0·80) and between left and right breasts for CWS (t=1·42, p=0·16) and volume of tissue receiving 95% isodose (t=−1·08, p=0·28). Significant difference between left (18–808 cGy) and right breast (325–365 cGy) was demonstrated for MLD (t=3·03, p=0·00). Conclusion This study demonstrated lack of correlation between breast size and MLD. Further research is recommended for justification of alternative techniques for this subgroup of patients to provide optimised radiotherapy delivery.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Healthcare Sciences
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Publisher: Cambridge University Press
ISSN: 1460-3969
Date of Acceptance: 3 February 2016
Last Modified: 04 Jun 2017 09:03
URI: http://orca.cf.ac.uk/id/eprint/89953

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