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Superior control of HIV-1 replication by CD8+T cells is reflected by their avidity, polyfunctionality, and clonal turnover

Almeida, Jorge R., Price, David, Papagno, Laura, Arkoub, Zaïna Aït, Sauce, Delphine, Bornstein, Ethan, Asher, Tedi E., Samri, Assia, Schnuriger, Aurélie, Theodorou, Ioannis, Costagliola, Dominique, Rouzioux, Christine, Agut, Henri, Marcelin, Anne-Geneviève, Douek, Daniel, Autran, Brigitte and Appay, Victor 2007. Superior control of HIV-1 replication by CD8+T cells is reflected by their avidity, polyfunctionality, and clonal turnover. Journal of Experimental Medicine 204 (10) , pp. 2473-2485. 10.1084/jem.20070784

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Abstract

The key attributes of CD8+ T cell protective immunity in human immunodeficiency virus (HIV) infection remain unclear. We report that CD8+ T cell responses specific for Gag and, in particular, the immunodominant p24 epitope KK10 correlate with control of HIV-1 replication in human histocompatibility leukocyte antigen (HLA)–B27 patients. To understand further the nature of CD8+ T cell–mediated antiviral efficacy, we performed a comprehensive study of CD8+ T cells specific for the HLA-B27–restricted epitope KK10 in chronic HIV-1 infection based on the use of multiparametric flow cytometry together with molecular clonotypic analysis and viral sequencing. We show that B27-KK10–specific CD8+ T cells are characterized by polyfunctional capabilities, increased clonal turnover, and superior functional avidity. Such attributes are interlinked and constitute the basis for effective control of HIV-1 replication. These data on the features of effective CD8+ T cells in HIV infection may aid in the development of successful T cell vaccines.

Item Type: Article
Status: Published
Schools: Medicine
Additional Information: Published PDF uploaded in accordance with policy at http://www.sherpa.ac.uk/romeo/issn/0022-1007/ [accessed 22/06/2016]
Publisher: Rockefeller University Press
ISSN: 0022-1007
Date of First Compliant Deposit: 27 April 2016
Date of Acceptance: 31 August 2007
Last Modified: 04 Jun 2017 09:04
URI: http://orca.cf.ac.uk/id/eprint/90109

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