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Alloreactive T cell clonotype recruitment in a mixed lymphocyte reaction: Implications for graft engineering

Scheinberg, Phillip, Price, David, Ambrozak, David R., Barrett, A. John and Douek, Daniel C. 2006. Alloreactive T cell clonotype recruitment in a mixed lymphocyte reaction: Implications for graft engineering. Experimental Hematology 34 (6) , pp. 788-795. 10.1016/j.exphem.2006.03.001

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Abstract

The selective elimination of alloreactive T cells from donor stem cell grafts prior to hematopoietic stem cell transplantation (HSCT) is an important goal in the prevention of graft-vs-host disease (GVHD). However, in HLA-identical donor-recipient pairs, it has proven difficult to identify alloreactive T cells using in vitro systems pretransplant due, in part, to their low frequency and a lack of methodological standardization. To better understand the alloresponse between HLA-identical related pairs, we characterized the alloreactive T cells generated in a mixed lymphocyte reaction (MLR) assay system.

Item Type: Article
Status: Published
Schools: Medicine
Subjects: Q Science > QH Natural history > QH426 Genetics
Publisher: Elsevier
ISSN: 0301-472X
Date of First Compliant Deposit: 3 May 2016
Date of Acceptance: 2 March 2006
Last Modified: 04 Jun 2017 09:05
URI: http://orca.cf.ac.uk/id/eprint/90319

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