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Significance and therapeutic implications of endothelial progenitorcells in angiogenic-mediated tumour metastasis

Flamini, Valentina, Jiang, Wen Guo, Lane, Jane and Cui, Yuxin 2016. Significance and therapeutic implications of endothelial progenitorcells in angiogenic-mediated tumour metastasis. Critical Reviews in Oncology/Hematology 100 , pp. 177-189. 10.1016/j.critrevonc.2016.02.010

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Abstract

Cancer conveys profound social and economic consequences throughout the world. Metastasis is respon-sible for approximately 90% of cancer-associated mortality and, when it occurs, cancer becomes almostincurable. During metastatic dissemination, cancer cells pass through a series of complex steps includingthe establishment of tumour-associated angiogenesis. The human endothelial progenitor cells (hEPCs)are a cell population derived from the bone marrow which are required for endothelial tubulogenesisand neovascularization. They also express abundant inflammatory cytokines and paracrine angiogenicfactors. Clinically hEPCs are highly correlated with relapse, disease progression, metastasis and treatmentresponse in malignancies such as breast cancer, ovarian cancer and non-small-cell lung carcinoma. It hasbecome evident that the hEPCs are involved in the angiogenesis-required progression and metastasis oftumours. However, it is not clear in what way the signalling pathways, controlling the normal cellularfunction of human BM-derived EPCs, are hijacked by aggressive tumour cells to facilitate tumour metas-tasis. In addition, the actual roles of hEPCs in tumour angiogenesis-mediated metastasis are not wellcharacterised. In this paper we reviewed the clinical relevance of the hEPCs with cancer diagnosis, pro-gression and prognosis. We further summarised the effects of tumour microenvironment on the hEPCsand underlying mechanisms. We also hypothesized the roles of altered hEPCs in tumour angiogenesisand metastasis. We hope this review may enhance our understanding of the interaction between hEPCsand tumour cells thus aiding the development of cellular-targeted anti-tumour therapies.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: Elsevier
ISSN: 1040-8428
Date of First Compliant Deposit: 12 May 2016
Date of Acceptance: 15 February 2016
Last Modified: 27 Jan 2018 19:34
URI: http://orca.cf.ac.uk/id/eprint/90344

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