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The impact of TIMM17A on aggressiveness of human breast cancer cells

Yang, Xiaomei, Si, Yang, Martin, Tracey Amanda and Jiang, Wen Guo 2016. The impact of TIMM17A on aggressiveness of human breast cancer cells. Anticancer Research 36 (3) , pp. 1237-1241.

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Abstract

Background: The mitochondrial protein translocase of inner mitochondrial membrane 17 homolog A (TIMM17A) has been identified as a biomarker of breast cancer. The present study aimed to investigate the biological role of TIMM17A in human breast cancer cells. Materials and Methods: Anti-TIMM17A transgenes were stably transfected into MDA MB-231 and MCF-7 breast cancer cell lines. The impact of TIMM17A knock-down on cell migration and invasion were evaluated using the respective cell models. Results: Reducing the expression of TIMM17A in breast cancer cells resulted in reduction of cell migration using electric cell-substrate impedance sensing. It was also found that reduction of TIMM17A expression resulted in reduction of cell invasion compared to vector control. Conclusion: TIMM17A has a profound impact on the cellular function of breast cancer cells. A decrease of TIMM17A expression is associated with the reduction of the aggressiveness of breast cancer cells. TIMM17A, therefore, has potential in prognosis and treatment of breast cancer.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: International Institute of Anticancer Research
ISSN: 0250-7005
Date of Acceptance: 23 February 2016
Last Modified: 18 Jun 2019 10:18
URI: http://orca.cf.ac.uk/id/eprint/90383

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